Southampton 2-3 Millwall

Southampton dumped out of the FA Cup.

Birmingham 1-0 Portsmouth

Nathan Redmond's brilliant, late winner helps Birmingham defeat Portsmouth 1-0 and move up to third in the Championship.

Sheffield Wed 0-3 Blackpool

Blackpool seal an FA Cup fifth-round trip to Everton after a convincing 3-0 victory at Sheffield Wednesday.

Swindon 1-0 Barnet (2-1)

Swindon edge Barnet to seal a 2-1 aggregate victory and reach the Johnstone's Paint Trophy final at Wembley.

Dunfermline 1-1 Kilmarnock

Dunfermline fail to climb off the bottom of the Premier League table despite a spirited draw with Kilmarnock at East End Park.

Obesity Epidemic Linked To Brain Mechanisms

America's rising rates of obesity in virtually all age groups is partly due to biological factors, researchers from the Cincinnati Diabetes and Obesity Center reported in the journal Cell Metabolism. Approximately one third of all American adults are obese today, and the percentage continues to rise, says the CDC (Centers for Disease Control and Prevention). Co-author, Randy Seeley, PhD, said: "While we don't usually think of it this way, body weight is regulated...

Obama Plans To Combat Alzheimer's

A statement released by The Obama Administration claims there are going to be new measures taken against battling Alzheimer's disease. One of these efforts includes a $50 million increase in the amount of money that will be used towards new, advanced research. Also, the administration says their Fiscal Year 2013 budget will increase by $80 million for Alzheimer's exploration. The announcement adds that a $26 million increase will be made in terms of provider education, public awareness, advances in data infrastructure, and care-giver support...

Contador says ban an 'injustice'

Alberto Contador plans to appeal against a two-year drugs ban.

Spanking Undermines A Child's Long-Term Development

Spanking children may harm their long-term development, making them more aggressive towards their peers, siblings, parents, as well as spouses later in life, researchers from the University of Manitoba and Children's Hospital of Eastern Ontario, report in CMAJ (Canadian Medical Association Journal). Their study tracked children for two decades. Physical punishment refers to any type, regardless of its motive, be it out of frustration, desperation or love, the researchers explained...

National Black HIV/AIDS Awareness Day

President, Founder and CEO of Black AIDS Institute, Phill Wilson, released a letter in light of the 12th annual National Black HIV/AIDS Awareness Day, stating that the Institute will be releasing their 8th annual State of AIDS in Black America Report. He comments that "It will highlight a reality that would have been unthinkable not long ago. Wilson continues: "We are at a deciding moment in the trajectory of the AIDS epidemic; we now possesses the tools we need to the the AIDS epidemic...

Stoke lose Huth's red card appeal

VIDEO: BBC F1 team preview 2012 season

BBC F1 presenter Jake Humphrey is joined by chief analyst Eddie Jordan and co-commentator David Coulthard to look ahead to the 2012 F1 season, which starts in Melbourne on 16 March.

Is Economy Class Air Travel Linked To Blood Clot Risk? Apparently Not

"Economy Class Syndrome" is a myth, your risk of developing a blood clot during a long-distance economy trip by plane is not higher than in first class, researchers report in an article published in Chest. The American College of Chest Physicians (ACCP) has issued new evidence-based guidelines which address some of the risk factors linked to DVT (deep vein thrombosis) - it says that there is no compelling evidence linking economy class air travel to the development of DVT...

Parks stands down from Scotland

Raikkonen sets fastest test time

Lotus racer Kimi Raikkonen sets the fastest time on the first day of Formula 1 pre-season testing in Jerez, Spain.

Redknapp tax trial jury sent home

The jury in the Harry Redknapp tax evasion trial is sent home for the day with deliberations to continue on Wednesday.

Online Dating Falls Short, But Offers Some Benefits

Online dating has become a billion dollar industry and is today a common way for people to meet potential mates - however, a new report written by researchers from Northwestern University and published in Psychological Science in the Public Interest has said that online dating websites fall short of their potential, make several phony claims, but do offer some benefits. Just two decades ago, online dating did not exist. Nowadays, thousands of websites claim to be able to help us seek out our long-lost soulmate, and set us on our way to living happily ever after...

Terry not ready to quit England

News From The Journal Of Clinical Investigation: Feb. 6, 2012

IMMUNOLOGY: How a stomach-colonizing bacterium protects against asthma The bacterium Helicobacter pylori can be found colonizing the stomach lining of almost half the world's population. Although persistent infection with Helicobacter pylori increases an individual's risk of developing stomach cancer, it also decreases their risk of developing asthma. A team of researchers led by Anne Muller, at the University of Zürich, Switzerland, has now identified a cellular mechanism by which persistent infection with Helicobacter pylori protects mice from developing allergic asthma...

Based On CE Analysis Of Oral Medications, ACP Recommends Metformin To Treat Type 2 Diabetes

The American College of Physicians (ACP) recommends that clinicians add metformin as the initial drug treatment for most patients with type 2 diabetes when lifestyle modifications such as diet, exercise, and weight loss have failed to adequately improve high blood sugar. ACP also recommends that clinicians add a second drug to metformin when treatment with metformin and lifestyle changes fail to control blood sugar levels. Citing insufficient evidence, ACP does not recommend one class of drug over another as a second medication...

A Child's Long-Term Development May Be Harmed By Physical Punishment

An analysis of research on physical punishment of children over the past 20 years indicates that such punishment is potentially harmful to their long-term development, states an article in CMAJ (Canadian Medical Association Journal). Over the past 20 years, a growing body of research clearly indicates that children who have experienced physical punishment tend to be more aggressive toward parents, siblings, peers and, later, spouses, and are more likely to develop antisocial behaviour...

More Accurate Diagnosis Of Genetic Mutations Expected Using New Virtual Tool

DNA sequencing to detect genetic mutations can aid in the diagnosis and selection of treatment for cancer. Current methods of testing DNA samples, Sanger sequencing and pyrosequencing, occasionally produce complex results that can be difficult or impossible to interpret. Scientists at the Johns Hopkins University School of Medicine have developed a free software program, Pyromaker, that can more accurately identify such complex genetic mutations...

Preventing Obesity Through Positive Parenting During Early Childhood

Programs that support parents during their child's early years hold promise for obesity prevention, according to a new study in the online issue of Pediatrics. Today, one out of five American children is obese. Young children who are overweight are five times more likely than their peers of normal weight to be obese by adolescence. Obese children and adolescents, especially low-income and minority youth, are at increased risk for a range of medical, social and academic problems...

How Autoreactive T Cells Slip Through The Cracks

Immune cells capable of attacking healthy organs "see" their targets differently than do protective immune cells that attack viruses, according to work published online this week in the Journal of Experimental Medicine. During development, T lymphocytes are screened for their ability to recognize normal tissue. Such autoreactive cells are typically purged, but some slip by these safeguards and may contribute to autoimmune disease...

Taste Receptors Discovered In Pancreatic Beta Cells Can Sense Fructose And Stimulate Insulin Secretion

Taste receptors on the tongue help us distinguish between safe food and food that's spoiled or toxic. But taste receptors are now being found in other organs, too. In a study published online the week of February 6 by the Proceedings of the National Academy of Sciences of the USA, researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) discovered that beta cells in the pancreas use taste receptors to sense fructose, a type of sugar. According to the study, the beta cells respond to fructose by secreting insulin, a hormone that regulates the body's response to dietary sugar...

As A Control Measure During Pandemic Outbreaks, School Closures Should Be Considered

Closing elementary and secondary schools can help slow the spread of infectious disease and should be considered as a control measure during pandemic outbreaks, according to a McMaster University led study. Using high-quality data about the incidence of influenza infections in Alberta during the 2009 H1N1 flu pandemic, the researchers show that when schools closed for the summer, the transmission of infection from person to person was sharply reduced...

Increased Risk Of Fatal Side Effects From 3 'Targeted' Cancer Drugs

Treatment with three relatively new "targeted" cancer drugs has been linked to a slightly elevated chance of fatal side effects, according to a new analysis led by scientists at Dana-Farber Cancer Institute. They added that the risk remains low, but should be taken into account by physicians and patients. The incidence of fatal complications was 1.5 percent in patients who received any of the three drugs, which block the vascular endothelial growth factor (VEGF) tyrosine kinase receptors in cancer cells, according to the study published February 6 in the Journal of Clinical Oncology...

The Pathway To Losing Fat Is Heavily Influenced By A Hormone Produced In The Heart

It's well known that exercising reduces body weight because it draws on fat stores that muscle can burn as fuel. But a new study at Sanford-Burnham Medical Research Institute (Sanford-Burnham) suggests that the heart also plays a role in breaking down fat. In their study, published February 6 in the Journal of Clinical Investigation, Sheila Collins, Ph.D. and colleagues detail how hormones released by the heart stimulate fat cell metabolism. These hormones turn on a molecular mechanism similar to what's activated when the body is exposed to cold and burns fat to generate heat...

Researchers Find Additional Benefits Of Cord Blood Cells In Mice Modeling ALS

Repeated, low-dose injections of mononuclear cells derived from human umbilical cord blood (MNC hUCB, tradename: U-CORD-CELLâ„¢) have been found effective in protecting motor neuron cells, delaying disease progression and increasing lifespan for mice modeling amyotrophic lateral sclerosis, or ALS, also referred to as Lou Gehrig's disease, report University of South Florida researchers and colleagues from Saneron CCEL Therapeutics, Inc., and the Ribeirao Preto School of Medicine at the University of Sao Paulo, Brazil. Their study was published online in the journal PLoS ONE...

New Prostate Cancer Drug Target Identified

Research led by Wanguo Liu, PhD, Associate Professor of Genetics at LSU Health Sciences Center New Orleans, has identified a new protein critical to the development and growth of prostate cancer. The findings are published online in the Early Edition of Proceedings of the National Academy of Sciences, available the week of February 6, 2012. Dr. Liu and his team discovered a protein called ARD1 which is involved with the male hormone, androgen, and its receptor. Prostate cancer is a hormone-regulated disease and the main hormone is androgen...

Simultaneously Confronting HIV/AIDS, Malaria, And The Need For Clean Water Improves Health At A Lower Cost

The great paradox of global health efforts is that regions of the world most plagued by poverty, poor infrastructure and rampant disease are often the most difficult to deliver care to. In addition, when development and public health agencies focus their efforts on one individual disease or another, instead of taking a unified approach, their programs can work at cross-purposes, contributing to rising costs and lost lives...

Clues To Common Birth Defect Found In Gene Expression Data

Researchers at MassGeneral Hospital for Children (MGHfC), The Jackson Laboratory and other institutes have uncovered 27 new candidate genes for congenital diaphragmatic hernia (CDH), a common and often deadly birth defect. Their sophisticated data-filtering strategy, which uses gene expression during normal development as a starting point, offers a new, efficient and potentially game-changing approach to gene discovery...

Directing Stem Cells To Increase Bone Formation And Bone Strength

A research team led by UC Davis Health System scientists has developed a novel technique to enhance bone growth by using a molecule which, when injected into the bloodstream, directs the body's stem cells to travel to the surface of bones. Once these cells are guided to the bone surface by this molecule, the stem cells differentiate into bone-forming cells and synthesize proteins to enhance bone growth...

New Analysis Finds No Antidepressant-Suicide Link In Youths

In 2004, concerns about antidepressant drugs increasing suicidal thoughts and behaviors in young patients prompted the FDA to issue a rare "black box warning." Now, a new analysis of clinical trial data finds that treatment with the antidepressant fluoxetine did not increase - or decrease - suicidality in children compared to placebo treatment. An analysis built on data from 41 trials and more than 9,000 patients also found that two different popular antidepressant drugs were effective at reducing suicidal behavior and depressive symptoms in adult and geriatric patients...

A Particular Breast Cancer Subtype May Respond To Drugs Targeting Chromosomal Instability

Another layer in breast cancer genetics has been peeled back. A team of researchers at Jefferson's Kimmel Cancer Center (KCC) led by Richard G. Pestell, M.D., PhD., FACP, Director of the KCC and Chair of the Department of Cancer Biology, have shown in a study published online in the Journal of Clinical Investigation that the oncogene cyclin D1 may promote a genetic breakdown known as chromosomal instability (CIN). CIN is a known, yet poorly understood culprit in tumor progression...

News From The Annals Of Internal Medicine: Feb. 7 2012

1. American College of Physicians Issues New Clinical Practice Guideline for Drug Treatment of Type 2 Diabetes ACP Recommends Metformin to Treat Type 2 Diabetes Based on Comparative Effectiveness Analysis of Oral Medications The American College of Physicians (ACP) recommends that clinicians add metformin as the initial drug treatment for most patients with type 2 diabetes when lifestyle modifications such as diet, exercise, and weight loss have failed to adequately improve high blood sugar...

Smoking Speeds Up Male Cognitive Decline

A male regular smoker has a higher risk of rapid cognitive decline, compared to his counterparts who do not smoke, researchers from University College London, England, reported in Archives of General Psychiatry. The authors add that the evidence has been mounting regarding the link between smoking and dementia in elderly individuals - smoking has been found to push up the total number of patients with dementia around the world. Séverine Sabia, Ph.D., and team set out to determine what impact smoking might have on men during their transition from middle age to old age...

Key To Immune Cell's 'internal Guidance' System Discovered

University of British Columbia researchers have discovered the molecular pathway that enables receptors inside immune cells to find, and flag, fragments of pathogens trying to invade a host. The discovery of the role played by the molecule CD74 could help immunologists investigate treatments that offer better immune responses against cancers, viruses and bacteria, and lead to more efficient vaccines. The findings are published in this week's edition of Nature Immunology...

Faster, More Efficient Protein Labeling Developed By Chemists

North Carolina State University researchers have created specially engineered mammalian cells to provide a new "chemical handle" which will enable researchers to label proteins of interest more efficiently, without disrupting the normal function of the proteins themselves or the cells in which they are found. Protein labeling is used by researchers in a variety of fields to help them understand how these important molecules affect the normal functioning of cells...

Potential Biomarker Identified For Osteoarthritis

Henry Ford Hospital researchers have identified for the first time two molecules that hold promise as a biomarker for measuring cartilage damage associated with osteoarthritis. Researchers say the concentration of two molecules called non-coding RNAs in blood were associated with mild cartilage damage in 30 patients who were one year removed from reconstruction surgery to repair an anterior cruciate ligament, or ACL, injury...